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RESEARCH

• Perspective

  Translating cancer research into targeted therapeutics

  

  • J. S. de Bono &
   
  • Alan Ashworth

  • Drug discovery

• Letter

  Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

  

  • Hugo Mouquet,
   
  • Johannes F. Scheid,
   
  • Markus J. Zoller,
   
  • Michelle Krogsgaard,
   
  • Rene G. Ott
  • + et al

  • Immunology
  • Molecular biology
  • Virology

• News and Views

  Water resources: Beyond infrastructure

  

  • Margaret A. Palmer

  • Environmental science

• News and Views

  Low-temperature physics: Paired in one dimension

  

  • Immanuel Bloch

  • Physics

• News and Views

  HIV: Antibodies with a split personality

  

  • Andreas Plückthun

  • Disease
  • Immunology
  • Molecular biology
  • Show 1 more

• News and Views

  Biogeochemistry: Ocean biomes blended

  

  • Raymond N. Sambrotto

  • Environmental science
  • Earth science

• Article

  Ocean nutrient ratios governed by plankton biogeography

  

  • Thomas S. Weber &
   
  • Curtis Deutsch

  • Earth science

• Article

  Global threats to human water security and river biodiversity

  

  • C. J. Vörösmarty,
   
  • P. B. McIntyre,
   
  • M. O. Gessner,
   
  • D. Dudgeon,
   
  • A. Prusevich
   
  • + et al

  • Environmental science

• Letter

  Spin-imbalance in a one-dimensional Fermi gas

  

  • Yean-an Liao,
   
  • Ann Sophie C. Rittner,
   
  • Tobias Paprotta,
   
  • Wenhui Li,
   
  • Guthrie B. Partridge
  • + et al

  • Applied physics and engineering

• Letter

  Generation of three-qubit entangled states using superconducting phase qubits

  

  • Matthew Neeley,
   
  • Radoslaw C. Bialczak,
   
  • M. Lenander,
   
  • E. Lucero,
   
  • Matteo Mariantoni
   
  • + et al

  • Applied physics and engineering

• Letter

  Preparation and measurement of three-qubit entanglement in a superconducting circuit

  

  • L. DiCarlo,
   
  • M. D. Reed,
   
  • L. Sun,
   
  • B. R. Johnson,
  • J. M. Chow
   
  • + et al

  • Applied physics and engineering
  • Computing science
  • Information technology

• Letter

  Vertical extension of the subglacial drainage system into basal crevasses

  

  • Joel T. Harper,
   
  • John H. Bradford,
   
  • Neil F. Humphrey &
   
  • Toby W. Meierbachtol

  • Climate science
  • Geology and geophysics

• Letter

  Decay of aftershock density with distance does not indicate triggering by dynamic stress

  

  • Keith Richards-Dinger,
   
  • Ross S. Stein &
   
  • Shinji Toda

  • Geology and geophysics

• Letter

  Two enzymes bound to one transfer RNA assume alternative conformations for consecutive reactions

  

  • Takuhiro Ito &
   
  • Shigeyuki Yokoyama

  • Biochemistry
  • Biophysics
  • Molecular biology

• Letter

  Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

  

  • Daniel Schramek,
   
  • Andreas Leibbrandt,
   
  • Verena Sigl,
   
  • Lukas Kenner,
   
  • John A. Pospisilik
   
  • + et al

  • Cancer
  • Medical research
  • Physiology

• Letter

  Hundreds of variants clustered in genomic loci and biological pathways affect human height

  

  • Hana Lango Allen,
   
  • Karol Estrada,
   
  • Guillaume Lettre,
   
  • Sonja I. Berndt,
   
  • Michael N. Weedon
  • + et al

  • Genetics and genomics

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SPECIALS

See all specials

• Translational cancer research

  

  Translational cancer research is forging ahead at an increasing pace. As the molecular pathways that are disturbed in cancer are being unravelled, new therapeutic targets are being identified and novel drugs are being developed. These advances are being translated into clinical trials with a view to providing personalized cancer care, in which the genetic makeup of an individual tumour and other biomarkers can predict the combination of treatments that it will best respond to.

   

  Find out more in our web focus

• Sex and stigma

  

  This week's Nature Video presents Françoise Barré-Sinoussi who won her Nobel Prize for identifying HIV as the cause of AIDS. The virus is made more dangerous by the social stigmas that surround infection. Young physicist Markita Landry explores social and educational issues in HIV research with Françoise. The pair also share their experiences of life as women working in science.

   

  Watch the latest video from the 2010 Meeting of Nobel Laureates